J Korean Radiol Soc.  1982 Sep;18(3):629-635. 10.3348/jkrs.1982.18.3.629.

The radioimmunoassay of serum CEA levels with clinical analysis

• Choi KA
• Yoo KH
• Lee NJ
• Chung KB
• Lee MJ

• KMID: 2463291
• DOI: http://doi.org/10.3348/jkrs.1982.18.3.629

Abstract

The CEA(carcinoembryonic antigen) was discovered in the blood of the patient in the colon cancer by Gold andFreedmann,(1965). Subsequent development of radioimmunoassay by Thomson et al (1969) made it possible to detectthe very low concentrations of CEA in circulating blood, other body fluids and also in normal, benign andmalignant subjects. Recently, the serum CEA levels is used as complementary diagnostic method and therapeuticindicatiors in malignant patients, especially colorectal cancers. The authors detected CEA in serum by employingsandwitch solid-phase radioimmunoassay of 22 normal controls, 51 of various benign diseases and 60 of variousmalignant diseases during period of 7 months from Feb. to Aug. 1981 in Korea University Hospital. The results wereas follows; 1. In the 22 cases of control group, the mean value of serum CEA was 1.62±1.02ng/ml. (smoker ...2.23±1.34ng/ml. non-smoker...1.01±0.66ng/ml). 2. In the 51 cases of benign diseases, the mean value of serum CEAwas 4.53±2.54ng/ml. (p value less than 0.005) 3. In the 60 cases of malignant diseases, the mean value of serumwas 13.60±11.25ng/ml.(P value less than 0.005) 4. In the 5 cases of liver metastasis, the mean value of the serumCEA levels were very high as compared with primary hepatic carcinoma.

MeSH Terms

Body Fluids
Colonic Neoplasms
Colorectal Neoplasms
Humans
Korea
Liver
Methods
Neoplasm Metastasis
Radioimmunoassay*