Korean J Pancreas Biliary Tract.  2019 Jul;24(3):121-126. 10.15279/kpba.2019.24.3.121.

Complete Remission of Metastatic Duodenal Neuroendocrine Carcinoma Treated with Chemotherapy and Surgical Resection

  • 1Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea. jkryu@snu.ac.kr


A 57-year-old male with periampullary duodenal mass was diagnosed as grade 3 duodenal neuroendocrine carcinoma with multiple liver metastasis. After nine cycles of cisplatin and etoposide, abdominal computed tomography (CT) findings showed complete regression of primary duodenal mass with marked size reduction of liver metastasis. Positron emission tomography findings showed metabolic complete response in both duodenal and liver mass. Pylorus-preserving pancreaticoduodenectomy was done and pathologic finding showed 5 mm sized remnant neuroendocrine tumor. The patient has remained alive with no evidence of disease for 43 months after initial diagnosis. This case suggests the possibility of heterogeneous nature of grade 3 neuroendocrine carcinoma and selected population may have extreme sensitivity to cisplatin and etoposide chemotherapy leading to complete response.


Neuroendocrine tumors; Neoplasm metastasis; Induction chemotherapys
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