Psychiatry Investig.  2019 Mar;16(3):244-248. 10.30773/pi.2018.11.18.

Effect of tDCS on Aberrant Functional Network Connectivity in Refractory Hallucinatory Schizophrenia: A Pilot Study

  • 1Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea.
  • 2Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea.
  • 3Department of Psychiatry, Washington University in St. Louis, MO, USA.
  • 4Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.


We aim to investigate the effect of fronto-temporal transcranial direct current stimulation (tDCS) on the interactions among functional networks and its association with psychotic symptoms. In this pilot study, we will determine possible candidate functional networks and an adequate sample size for future research. Seven schizophrenia patients with treatment-refractory auditory hallucinations underwent tDCS twice daily for 5 days. Resting-state fMRI data and measures of the severity of psychotic symptoms were acquired at baseline and after completion of the tDCS sessions. At baseline, decreased functional network interaction was negatively correlated with increased hallucinatory behavior. After tDCS, the previously reduced functional network connectivity significantly increased. Our results showed that fronto-temporal tDCS could possibly remediate aberrant hallucination-related functional network interactions in patients with schizophrenia.


Neuroimaging; Schizophrenia and psychotic disorder; Transcranial direct current stimulation; Auditory hallucinations; Resting-state fMRI
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