J Pathol Transl Med.  2019 Jan;53(1):70-74. 10.4132/jptm.2018.11.09.

Cytopathologic Features of Secretory Carcinoma of Salivary Gland: Report of Two Cases

• Kim YA
• Joung JW
• Lee SJ
• Oh HK
• Cho CH
• Sung WJ

• KMID: 2437582
• DOI: http://doi.org/10.4132/jptm.2018.11.09

Abstract

Secretory carcinoma of the salivary gland (SC) is a newly introduced rare salivary gland tumor that shares histological, immunohistochemical, and genetic characteristics with secretory carcinoma of the breast. Here, we report the cytologic features of two cases of SC confirmed by surgical resection. In these two cases, SC was incidentally detected in a 64-year-old female and a 56-yearold male. Fine needle aspiration cytology revealed nests of tumor cells with a papillary or glandular structure floating in mucinous secretions. The tumor cells demonstrated uniform, round, smooth nuclear contours and distinct nucleoli. Multiple characteristic cytoplasmic vacuoles were revealed. Singly scattered tumor cells frequently showed variable sized cytoplasmic vacuoles. The cytopathologic diagnosis of SC should be considered when characteristic cytological findings are revealed. Further immunohistochemistry and gene analyses are helpful to diagnose SC.

Keyword

Secretory carcinoma; Mammary analogue secretory carcinoma; Salivary gland; Cytology

MeSH Terms

Biopsy, Fine-Needle
Breast
Clothing
Cytoplasm
Diagnosis
Female
Humans
Immunohistochemistry
Male
Mammary Analogue Secretory Carcinoma
Middle Aged
Mucins
Salivary Glands*
Vacuoles
Mucins

Figure

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  Fig. 1. Cytopathologic features of case 1. (A) The specimen has high cellularity and nest with papillary structure. (B) Mucinous background is easily recognized with scattered lymphocytes and individual tumor cells. (C) Tumor cells have uniform, round nuclei and distinct nucleoli. (D) Various sized cytoplasmic vacuoles (arrows) are noted. (E) Some macrovacuoles (arrow), similar to signet ring cells, may be seen. (F) Some tumor cells show binucleation (arrows) or eccentric nuclei (arrowheads). (G) The tumors consist of microcystic or follicular structures with eosinophilic secretions. (H) Strong diffuse immunoreactivity to S100 protein. (I) ETV6 fluorescence in situ hybridization showing one fused (arrowheads) and one split (red and green) signal indicative of ETV6 translocation.

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  Fig. 2. Cytopathologic features of case 2. (A) The specimen has low cellularity compared with case 1. (B) Loose trabecular nests of tumor cells are noted. (C) Hemosiderin laden macrophages are found. (D) Tumor cells have uniform, centrally located nuclei. (E) Tumor cells show eosinophilic and fine granular cytoplasm. (F) Sometimes, vacuolated cells (arrows) are encountered. (G) Tumor cells show microcystic, follicular architecture with eosinophilic secretions. (H) Strong immunoreactivity to mammaglobin is noted. (I) ETV6 fluorescence in situ hybridization showing one fused (arrowheads) and one split (red and green) signal indicative of ETV6 translocation.

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