Arch Aesthetic Plast Surg.  2018 Oct;24(3):116-127. 10.14730/aaps.2018.24.3.116.

For Better Fat Graft Outcome in Soft Tissue Augmentation: Systematic Review and Meta-Analysis

Affiliations
  • 1Department of Plastic and Reconstructive Surgery, MyongJi Hospital, Goyang, Korea. gabriel@mjh.or.kr

Abstract

BACKGROUND
Autologous fat grafts are widely used in plastic surgery, but they have the disadvantage of unpredictability due to variable resorption. This meta-analysis examined the literature on the survival rate of autologous fat grafts using objective markers, and investigated the factors that affected the survival rate.
METHODS
The reviewers searched the PubMed, EMBASE, and Cochrane Library databases from January 2001 to December 2017. A meta-analysis was performed to estimate fat graft survival and to identify variables that influenced the survival rate.
RESULTS
A total of 27 studies (1,066 cases) were included in the meta-analysis. The mean survival rate of grafted fat was 56.5%. The survival rate was significantly higher for cell-assisted lipotransfer (CAL) than for non-CAL (62% vs. 53.4%; P=0.015). The survival rate for procedures performed to correct lipoatrophy was higher than that of procedures performed for other purposes (64.6%; P=0.014), and was significantly higher in patients who underwent breast pre-expansion using the BRAVA device (66.2% vs. 50.35%; P=0.001). There were no significant differences in the survival rate according to the recipient site, harvesting method, or refinement method.
CONCLUSIONS
Fat transplantation showed a varying survival rate, with an average of 56%. In patients who underwent CAL or breast pre-expansion with the BRAVA device, the survival rate of transplanted fat was higher than in their counterparts, supporting the use of these techniques in fat transplantation.

Keyword

Adult stem cells; Analysis of variance; Autografts

MeSH Terms

Adult Stem Cells
Analysis of Variance
Autografts
Breast
Graft Survival
Humans
Methods
Surgery, Plastic
Survival Rate
Transplants*
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