Acute Crit Care.  2018 May;33(2):105-109. 10.4266/acc.2016.00164.

Chemical Pleurodesis Using Viscum album Extract in Gorham Disease Complicated with Chylothorax

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Korea.
  • 2Department of Thoracic and Cardiovascular Surgery, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Korea. 95swan@gmail.com

Abstract

Gorham disease, also known as massive osteolysis, is characterized by unregulated proliferation of lymphatic or vascular capillaries within bone, resulting in destruction and replacement with angiomatous tissue. This disease can lead to chylothorax that can be lethal. Viscum album extract from European mistletoe is a complementary anti-cancer drug which is commonly prescribed in many European countries and is considered as a new generation of chemical agent for pleurodesis. A 14-year-old girl presented with dyspnea and chest pain. She was diagnosed as Gorham disease who was definitively treated with V. album extract for chylothorax that was refractory to standard conservative management.

Keyword

chylothorax; osteolysis, essential; pleurodesis

MeSH Terms

Adolescent
Capillaries
Chest Pain
Chylothorax*
Dyspnea
Female
Humans
Osteolysis, Essential*
Pleurodesis*
Viscum album*
Viscum*
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