Blood Res.  2018 Sep;53(3):261-263. 10.5045/br.2018.53.3.261.

Low-grade follicular lymphoma involvement of the bone marrow with a mixed paratrabecular, diffuse, and massive pattern expressing typical mantle cell lymphoma immunophenotype CD23−/FMC7+: a case report

• Kim J
• Lim JH
• Jeong J
• Lee SH
• Jo JC
• Park SH

• KMID: 2429330
• DOI: http://doi.org/10.5045/br.2018.53.3.261

Abstract

No abstract available.

MeSH Terms

Bone Marrow*
Lymphoma, Follicular*
Lymphoma, Mantle-Cell*

Figure

• 

  Fig. 1 Peripheral blood smears, bone marrow aspiration and touch print, bone marrow biopsy, and immunohistochemical staining results of our case. (A) Neoplastic lymphoid cells found in peripheral blood smear showed small-to-medium, cleaved nuclei and scant amount of cytoplasm (indicated by red arrows, Wright-Giemsa stain, ×400). (B) Neoplastic lymphoid cells found in the bone marrow aspirates also showed a small-to-medium, cleavage nucleus, and scant amount of cytoplasm as morphologic features (indicated by red arrows, Wright-Giemsa stain, ×400). (C) Neoplastic lymphoid cells found in touch print of the bone marrow also showed similar morphologic features (indicated by red arrows, Wright-Giemsa stain, ×400). (D) Bone marrow biopsy section showed infiltration of neoplastic lymphoid cells with a mixture of paratrabecular (indicated by red circle) and intertrabecular (indicated by blue circles) infiltration pattern (hematoxylin and eosin stain, × 100). (E, F) Neoplastic lymphoid cell did not show positivity on CD3 and CD5 immunohistochemical staining (×100). (G) However, neoplastic lymphoid cells showed strong membranous positivity for CD20 immunohistochemical staining (×100). (H, I) Neoplastic lymphoid cells found in paratrabecular areas showed strong nuclear positivity for BCL6, but those found in intertrabecular areas showed weak nuclear positivity for BCL6 (×100 and ×200, respectively).

Reference

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