Transl Clin Pharmacol.  2018 Jun;26(2):56-59. 10.12793/tcp.2018.26.2.56.

Pharmacodynamic principles and the time course of delayed and cumulative drug effects

Affiliations
  • 1Department of Pharmacology & Clinical Pharmacology, University of Auckland, Auckland, New Zealand. n.holford@auckland.ac.nz

Abstract

This tutorial reviews the principles of the concentration "” effect relationship for the usual case when drug effects are delayed relative to changes in circulating concentrations. The key processes determining delay are distribution from the circulation to the receptor, binding to the receptor to produce a stimulus and translation of the receptor stimulus into an effect through turnover of physiological mediators. Some clinical outcomes are dependent on the accumulation of drug action which is predictable in terms of basic pharmacokinetic and pharmacodynamic concepts.

Keyword

Cumulative response; Delayed of drug effect; Receptor binding; Turnover models

MeSH Terms

Dose-Response Relationship, Drug
Models, Biological
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