Environ Health Toxicol.  2017 ;32(1):e2017012. 10.5620/eht.e2017012.

Does wastewater discharge have relations with increase of Turner syndrome and Down syndrome?

  • 1Department of Public Administration, Yonsei University, Seoul, Korea. intae9294@gmail.com


The purpose of this study is to examine whether water and air pollutants have a relationship with an increase in the genetic disorders Turner syndrome and Down syndrome, which are caused by congenital chromosomal abnormalities, and to generate a hypothesis about the genetic health effects of environmental pollutants. A panel regression based on random effect was conducted on Korea's metropolitan councils from 2012 to 2014. The dependent variable was the number of Turner syndrome and Down syndrome cases, and the main independent variables were those regarding the water and air pollution. Air pollutants did not have a significant impact on the number of Turner syndrome and Down syndrome cases; however, the increase in number of wastewater discharge companies did have a significant relationship with the number of cases. The more the number of wastewater discharge companies, the more the number Turner syndrome and Down syndrome cases were observed. Therefore, scientific investigation on water and air pollutants in relation with genetic health effects needs to be performed.


Turner syndrome; Down syndrome; Environmental pollutants; Wastewater discharge

MeSH Terms

Air Pollutants
Air Pollution
Chromosome Aberrations
Down Syndrome*
Environmental Pollutants
Turner Syndrome*
Waste Water*
Air Pollutants
Environmental Pollutants
Waste Water
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