Clin Psychopharmacol Neurosci.  2018 Feb;16(1):122-125. 10.9758/cpn.2018.16.1.122.

Combined Use of Duloxetine and Olanzapine in the Treatment of Urologic Chronic Pelvic Pain Syndromes Refractory to Conventional Treatment: A Case Report

  • 1Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, PR China.
  • 2Department of Urology, Shengjing Hospital of China Medical University, Shenyang, PR China.


Patients with urologic chronic pelvic pain syndromes (UCPPS) report interstitial cystitis/bladder pain syndrome and/or chronic prostatitis/chronic pelvic pain syndrome. The pathogenesis of these syndromes remains unclear and there is currently no standard treatment. UCPPS is, therefore, often misdiagnosed and its management is complex. The present case report involves a 62-year-old male patient with UCPPS whose main presentation is painful bladder filling and painful urgency refractory to conventional treatment with medication, which was successfully treated with the combined use of duloxetine and olanzapine. The combined use of duloxetine and olanzapine may become a new therapeutic option in the management of UCPPS.


Bladder pain; Painful urinary urgency; Duloxetine; Olanzapine; Anxiety
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