Diabetes Metab J.  2017 Dec;41(6):423-429. 10.4093/dmj.2017.41.6.423.

Glucagon-Like Peptide-1 Receptor Agonists for the Treatment of Type 2 Diabetes Mellitus: A Position Statement of the Korean Diabetes Association

• Kim HJ
• Park SO
• Ko SH
• Rhee SY
• Hur KY
• Kim NH
• Moon MK
• Lee BW
• Kim JH
• Choi KM
• on behalf of the Committee of Clinical Practice Guidelines of the Korean Diabetes Association

• KMID: 2398081
• DOI: http://doi.org/10.4093/dmj.2017.41.6.423

Abstract

The glucagon-like peptide-1 receptor agonists (GLP-1RAs) were recommended as a monotherapy or combination therapy with oral hypoglycemic agents or basal insulin in the position statement of the Korean Diabetes Association 2017 for pharmacological therapy. Many randomized clinical trials and systematic reviews report that GLP-1RAs have considerable glucose-lowering effect and lead to weight reduction and low risk of hypoglycemia when used as a monotherapy or combination therapy. The cardiovascular safety of GLP-1RAs has been assessed in several randomized clinical trials and systematic reviews. The results of cardiovascular outcome trials of long-acting GLP-1RAs (liraglutide, semaglutide) demonstrated cardiovascular benefits in subjects with type 2 diabetes mellitus and a high risk of cardiovascular disease. The GLP-1RA may be a choice of therapy when weight control and avoidance of hypoglycemia are important, and patients with high risk of cardiovascular disease might also favor choosing GLP-1RA.

Keyword

Cardiovascular benefit; Clinical practice guideline; Combination therapy; Glucagon-like peptide-1 receptor agonist; Hypoglycemia; Monotherapy

MeSH Terms

Cardiovascular Diseases
Diabetes Mellitus, Type 2*
Glucagon-Like Peptide 1*
Glucagon-Like Peptide-1 Receptor*
Humans
Hypoglycemia
Hypoglycemic Agents
Insulin
Weight Loss
Glucagon-Like Peptide 1
Glucagon-Like Peptide-1 Receptor
Hypoglycemic Agents
Insulin

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