Asia Pac Allergy.  2013 Jul;3(3):204-206. 10.5415/apallergy.2013.3.3.204.

Autoerythrocyte sensitization syndrome presenting with general neurodermatitis

• Oh IY
• Ko EJ
• Li K

• KMID: 2397315
• DOI: http://doi.org/10.5415/apallergy.2013.3.3.204

Abstract

Autoerythrocyte sensitization syndrome (AES) was first described by Gardner and Diamond in 1955, when four women with painful bruising were depicted. Patients with AES typically present with the development of recurrent, spontaneous, painful ecchymosis, frequently preceded by a prodrome of pain or itching of the skin. The patients are sensitive to their own red blood cells injected intradermally, and underlying coagulopathies are thought to be absent. We introduce a 70-year-old woman presenting with recurrent episodes of painful bruising on the trunk and extremities.

Keyword

Autoerythrocyte sensitization; Painful ecchymosis; Psychogenic purpura

MeSH Terms

Aged
Diamond
Ecchymosis
Erythrocytes
Extremities
Female
Humans
Neurodermatitis*
Pruritus
Skin
Diamond

Figure

• 

  Fig. 1 A 70-year-old woman presented with painful bruising on the trunk and extremities.

• 

  Fig. 2 Intradermal test for autoerythrocyte sensitization resulted ecchymotic reaction on the washed red blood cell and whole blood injection site, but no reaction was observed on the plasma and normal saline injection site.

Reference

1. Gardner FH, Diamond LK. Autoerythrocyte sensitization; a form of purpura producing painful bruising following autosensitization to red blood cells in certain women. Blood. 1955; 10:675–690.

2. Karatosun V, Satoğlu S, Günal I, Alptekin K. Autoerythrocyte sensitization (Gardner-Diamond) syndrome mimicking compartment syndrome. Arch Orthop Trauma Surg. 2003; 123:370–371.

3. Chatterjee M, Jaiswal AK. Painful bruising syndrome. Indian J Dermatol Venereol Leprol. 2002; 68:347–348.

4. Silny W, Marciniak A, Czarnecka-Operacz M, Zaba R, Schwartz RA. Gardner-Diamond syndrome. Int J Dermatol. 2010; 49:1178–1181.

5. Settle EC Jr. Autoerythrocyte sensitization successfully treated with antidepressants. JAMA. 1983; 250:1749–1750.

6. Lindahl MW. Psychogenic purpura: report of a case. Psychosom Med. 1977; 39:358–368.

7. Uthman IW, Moukarbel GV, Salman SM, Salem ZM, Taher AT, Khalil IM. Autoerythrocyte sensitization (Gardner-Diamond) syndrome. Eur J Haematol. 2000; 65:144–147.

8. Kirschner MH, Hofmann GO, Markewitz A, Hatz R, Mempel M. Osteosynthetic reconstruction in a patient with Gardner-Diamond syndrome. J Trauma. 1995; 38:392–395.