Clin Psychopharmacol Neurosci.  2017 Aug;15(3):222-228. 10.9758/cpn.2017.15.3.222.

The Relationship between the SNAP-25 Polymorphism and Omission Errors in Korean Children with Attention Deficit Hyperactivity Disorder

• Kim E
• Song DH
• Kim NW
• Sohn IJ
• Cheon KA

• KMID: 2388267
• DOI: http://doi.org/10.9758/cpn.2017.15.3.222

Abstract

OBJECTIVE
This study aimed to investigate the association between the synaptosomal-associated protein 25 kDa (SNAP-25) genotype and performance on the continuous performance test (CPT) in Korean children with attention-deficit/hyperactivity disorder (ADHD).
METHODS
Eighty-seven children with ADHD (mean age, 9.23±1.99 years) participated in this study. Omission errors, commission errors, reaction time, and reaction time variability on the CPT were analyzed. The single-nucleotide polymorphism (SNP) rs3746544 (1065 T>G) of SNAP-25 was genotyped to examine the association with CPT performance.
RESULTS
We found significantly more omission errors on the CPT among children with the TT genotype of SNAP-25 (t=2.56, p=0.012) after correcting for multiple testing.
CONCLUSION
Our results suggest the possible involvement of the SNAP-25 1065 T>G polymorphism in the inattention phenotype in children with ADHD. Further studies with more refined neuropsychological measures and much larger sample sizes are needed to confirm our findings.

Keyword

Attention deficit disorder with hyperactivity; SNAP-25; Continuous performance test; Omission errors

MeSH Terms

Attention Deficit Disorder with Hyperactivity*
Child*
Genotype
Humans
Phenotype
Reaction Time
Sample Size
Synaptosomal-Associated Protein 25
Synaptosomal-Associated Protein 25