Ann Dermatol.  2011 Nov;23(4):539-543.

Congenital and Multiple Hobnail Hemangiomas

• Yoon SY
• Kwon HH
• Jeon HC
• Lee JH
• Cho S

Abstract

Hobnail hemangioma (targetoid hemosiderotic hemangioma) is a vascular tumor affecting the limbs or trunk. Characteristically, the lesion has a "targetoid" clinical feature and dilated vascular spaces lined by hobnail endothelial cells at histologic examination. The age of onset is widely variable, form 5~67 years, typically occurring in young or middle-aged persons. It is usually apparent as a small solitary lesion. However, multiple lesions are identified sometimes. Herein, we report two cases of hobnail hemangioma in 7-year-old and 15-year-old males. Of note, the former case had a congenital lesion and the latter, multiple acquired lesions, which are both rare atypical presentations of the disease.

Keyword

Congenital; Hemangioma; Multiple

MeSH Terms

Adolescent
Age of Onset
Child
Endothelial Cells
Extremities
Hemangioma
Humans
Male

Figure

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  Fig. 1 A dark brown papule with ecchymotic halo on left upper back (case 1).

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  Fig. 2 (A) Wedge-shaped architecture and dilated vessels in the upper dermis (H&E, ×40). (B) Intraluminal papillary projection and hobnail endothelial cells lining superficial vessels (H&E, ×400). (C) Collagen-dissecting, rather narrow vessels and numerous extravasated erythrocytes in deeper dermis (H&E, ×400).

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  Fig. 3 Strongly positive reaction with CD31 (A) and focal positive reaction with D2-40 (B) (×100).

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  Fig. 4 Two dusky red to brown plaques with surrounding ecchymotic macular rings on the left knee (case 2).

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  Fig. 5 (A) Intraluminal papillary projection and hobnail endothelial cells lining superficial dilated vessels (H&E, ×400). (B) Hemosiderin deposits in deeper dermis (H&E, ×400).

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