Korean J Dermatol.  2016 Jun;54(5):368-371.

A Case of Gorham-Stout Disease with Progressive Cutaneous Involvement

• Kim T
• Jeong KH
• Shin MK
• Kim NI

Abstract

Gorham-Stout disease is a rare bone disorder that is characterized by angiomatous proliferation and results in destruction and resorption of the osseous matrix. It has variable presentations and a number of different sites may be affected, including the dermis, soft tissue, and viscera. The involved cutaneous and soft tissue lesions typically present with sponge-like, soft, brown or purple lesions. The clinical course is generally prolonged, with eventual stabilization of the affected bone; however, it is rarely fatal. There is no standard treatment defined for this disease, and variable therapies such as medical, surgical, and radiation therapy have been used. We report a case of 24-year-old man with Gorham disease who presented with progressive cutaneous lesions and severe lymphedema adjacent to the diseased bone.

Keyword

Gorham-Stout disease; Lymphangiomatosis

MeSH Terms

Dermis
Humans
Lymphedema
Osteolysis, Essential*
Viscera
Young Adult