Ann Dermatol.  2017 Jun;29(3):334-336. 10.5021/ad.2017.29.3.334.

Eccrine Squamous Syringometaplasia Associated with Pelubiprofen Therapy

Affiliations
  • 1Department of Dermatology, Veterans Health Service Medical Center, Seoul, Korea. zooooz@hanmail.net

Abstract

Eccrine squamous syringometaplasia (ESS) is a histologically distinctive skin eruption occurring predominantly in acral or intertriginous areas presenting as erythematous macules, papules or patches. The etiology of ESS remains unclear, but it is usually reported in patients receiving chemotherapy for various malignant neoplasms. To date, only two cases of ESS associated with non-steroidal anti-inflammatory drugs (NSAIDs), which has distinctive clinical features and pathogenesis, have been reported in the literature. Herein, we report a rare and interesting case of ESS associated with pelubiprofen, a recently developed NSAID, which appeared after pelubiprofen therapy and resolved spontaneously after discontinuing the medication.

Keyword

Eccrine squamous syringometaplasia; Metaplasia; Pelubiprofen; Phototoxicity

MeSH Terms

Dermatitis, Phototoxic
Drug Therapy
Humans
Metaplasia
Skin

Figure

  • Fig. 1 Multiple scattered erythematous papules on the forehead (A) and neck (B).

  • Fig. 2 (A) Biopsy specimen from the neck shows numerous tubular structures and cellular infiltrations on the upper dermis (H&E, ×100). (B) Squamous syringometaplasia (arrows) on the neck (H&E, ×400).

  • Fig. 3 At the 4-weeks follow-up, all lesions resolved spontaneously on the forehead (A) and neck (B).


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