Blood Res.  2017 Mar;52(1):71-73. 10.5045/br.2017.52.1.71.

A case of lymphocytic variant hypereosinophilic syndrome with sub-diagnostic systemic mastocytosis

• Jain P
• Wang SA
• Yin CC
• Abaza Y
• Verstovsek S
• Estrov Z

• KMID: 2375210
• DOI: http://doi.org/10.5045/br.2017.52.1.71

Abstract

No abstract available.

MeSH Terms

Hypereosinophilic Syndrome*
Mastocytosis, Systemic*

Figure

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  Fig. 1 Morphologic and immunophenotypic features of the bone marrow biopsy and aspirate. (A) Bone marrow core biopsy shows hypercellular bone marrow with trilineage hematopoiesis and markedly increased eosinophils (H&E, ×200). (B) Bone marrow aspirate smear shows increased eosinophils, black arrows (Wright-Giemsa, ×500). (C) Immunohistochemical stain for CD5 shows a few scattered T cells (CD5, ×500). (D) Immunohistochemical stain for CD117 shows slightly increased atypical spindle-shaped mast cells (black arrows) with interstitial distribution (500) representing subdiagnostic mastocytosis.

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  Fig. 2 Flow cytometry analysis of bone marrow aspirate detected a minor population of aberrant T cells (about 0.52% of total cells) coexpressing CD4, CD5 with partial loss of CD7 (upper panel) and CD2 expression (not shown), and an aberrant population of cells coexpressing CD25 and CD117 mast cells (0.04%) (lower panel).

Reference

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