Yonsei Med J.  2016 Jul;57(4):900-904. 10.3349/ymj.2016.57.4.900.

Early Marker of Myocardial Deformation in Children with Duchenne Muscular Dystrophy Assessed Using Echocardiographic Myocardial Strain Analysis

• Jo WH
• Eun LY
• Jung JW
• Choi JY
• Gang SW

• KMID: 2374121
• DOI: http://doi.org/10.3349/ymj.2016.57.4.900

Abstract

PURPOSE
As cardiomyopathy is more prevalent and currently the leading cause of death in Duchenne muscular dystrophy (DMD), early detection of myocardial involvement is important. The purpose of this study was to analyze myocardial strain in DMD children, for the possibility of early detection of myocardial dysfunction.
MATERIALS AND METHODS
We reviewed medical records of DMD patients who were >10 years of age (15.6±1.6 years, 12.5-18 years), from March 2013 to June 2014. Data of 24 DMD children who underwent echocardiography with three-layer specific myocardial strain were compared with 24 controls (age: 9.3±4.0 years, 5.5-17 years).
RESULTS
Epicardial longitudinal strain was lower in DMD (DMD: -9.3±3.8%; control: -12.3±4.3%; p=0.012). Radial strain (DMD: 24.1±11.1%; control: 37.3±25.9%; p=0.027) and strain rate (SR) (DMD: 1.68±0.91; control: 2.42±0.84; p=0.006) on parasternal short axis view were lower in DMD. Circumferential strains in the endocardium (DMD: -17.5±4.7%; control: -24.2±5.3%; p<0.001), myocardium (DMD: -12.7±3.8%; control: -18.0±4.0%; p<0.001), and epicardium (DMD: -8.4±4.0%; control: -12.2±5.0%; p=0.006) were significantly decreased in DMD. Circumferential SRs were lower in the endocardial (DMD: -1.46±0.38; control: -1.78±0.27; p=0.002) and myocardial layers (DMD: 1.02±0.27; control: -1.28±0.22; p=0.001).
CONCLUSION
In DMD patients, deteriorations in myocardial circumferential strain might be an indicator for predicting cardiomyopathy.

Keyword

Duchenne muscular dystrophy; children; myocardial strain; cardiomyopathies

MeSH Terms

Adolescent
Cardiomyopathies/*diagnostic imaging/*etiology
Case-Control Studies
Child
Child, Preschool
Early Diagnosis
*Echocardiography
Female
Humans
Male
Muscular Dystrophy, Duchenne/*complications/*diagnostic imaging
Predictive Value of Tests

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