J Korean Med Sci.  2016 May;31(5):814-816. 10.3346/jkms.2016.31.5.814.

Calculation of the Residual Blood Volume after Acute, Non-Ongoing Hemorrhage Using Serial Hematocrit Measurements and the Volume of Isotonic Fluid Infused: Theoretical Hypothesis Generating Study

• Oh WS
• Chon SB

• KMID: 2373683
• DOI: http://doi.org/10.3346/jkms.2016.31.5.814

Abstract

Fluid resuscitation, hemostasis, and transfusion is essential in care of hemorrhagic shock. Although estimation of the residual blood volume is crucial, the standard measuring methods are impractical or unsafe. Vital signs, central venous or pulmonary artery pressures are inaccurate. We hypothesized that the residual blood volume for acute, non-ongoing hemorrhage was calculable using serial hematocrit measurements and the volume of isotonic solution infused. Blood volume is the sum of volumes of red blood cells and plasma. For acute, non-ongoing hemorrhage, red blood cell volume would not change. A certain portion of the isotonic fluid would increase plasma volume. Mathematically, we suggest that the residual blood volume after acute, non-ongoing hemorrhage might be calculated as 0·25N/[(Hct1/Hct2)-1], where Hct1 and Hct2 are the initial and subsequent hematocrits, respectively, and N is the volume of isotonic solution infused. In vivo validation and modification is needed before clinical application of this model.

Keyword

Blood Volume Determination; Hematocrit; Isotonic Solutions; Hemorrhagic Shock; Traumatic Shock

MeSH Terms

Blood Volume
Hematocrit
Humans
Isotonic Solutions/*therapeutic use
*Models, Theoretical
Shock, Hemorrhagic/*prevention & control/*therapy
Isotonic Solutions

Figure

• 

  Fig. 1 The change in red blood cell volume (RBCV), plasma volume (PV), blood volume (BV), and hematocrit (Hct) according to time after acute, non-ongoing hemorrhage.

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