J Gastric Cancer.  2011 Mar;11(1):31-37.

Metachronous Ovarian Metastases Following Resection of the Primary Gastric Cancer

• Jun SY
• Park JK

Abstract

PURPOSE
We performed this study to evaluate the clinical presentation as well as the proper surgical intervention for ovarian metastasis from gastric cancers and these tumors were identified during postoperative follow-up. This will help establish the optimal strategy for improving the survival of patients with this entity.
MATERIALS AND METHODS
22 patients (3.2%) with ovarian metastasis were noted when performing a retrospective chart review of (693) females patients who had undergone a resection for gastric cancer between 1981 and 2008. The covariates used for the survival analysis were the patient age at the time of ovarian relapse, the size of the tumor, the initial TNM stage of the gastric cancer, the interval to metastasis and the presence of gross residual disease after treatment for Krukenberg tumor. The cumulative survival curves for the patient groups were calculated with the Kaplan-Meier method and they were compared by means of the Log-Rank test.
RESULTS
The average age of the patients was 48.6 years (range: 24 to 78 years) and the average survival time of the 22 patients was 18.8 months (the estimated 3-year survival rate was 15.8%) with a range of 2 to 59 months after the diagnosis of Krukenberg tumor. The survival rate for patients without gross residual disease was longer than that of the patients with gross residual disease (P=0.0003). In contrast, patient age, the size of ovarian tumor, the initial stage of gastric adenocarcinoma, the interval to metastasis and adjuvant chemotherapy were not prognostic indicators for survival after the development of ovarian metastasis.
CONCLUSIONS
Early diagnosis and complete resection are the only possible hope to improve survival. As the 3-year survival rate after resection of Krukenberg tumor is 15.8%, it seems worthwhile to consider performing tumorectomy as the second cytoreduction.

Keyword

Krukenberg tumor; Stomach neoplasms; Survival

MeSH Terms

Adenocarcinoma
Chemotherapy, Adjuvant
Early Diagnosis
Female
Follow-Up Studies
Humans
Krukenberg Tumor
Neoplasm Metastasis
Recurrence
Retrospective Studies
Stomach Neoplasms
Survival Rate

Figure

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  Fig. 1 Overall survival curves for the patients with Krukenberg tumor from gastric cancer. The patients without gross residual disease survived longer than the patients with gross residual disease (P=0.0003).

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