Korean J Vet Res.  2016 Sep;56(3):133-137. 10.14405/kjvr.2016.56.3.133.

Changes in bispectral index score and cardiorespiratory function under constant rate infusion with alfaxalone in dogs

• Yun S
• Kwon YS

• KMID: 2368758
• DOI: http://doi.org/10.14405/kjvr.2016.56.3.133

Abstract

Changes in the cardiovascular and bispectral index score were evaluated in dogs subjected to constant rate infusion (CRI) with alfaxalone. Fifteen dogs were assigned to three groups of 5. Groups and doses of alfaxalone were as follows: group 1, 3 mg/kg for induction and 6 mg/kg/h for CRI; group 2, 3 mg/kg for induction and 8 mg/kg/h for CRI; and group 3, 3 mg/kg for induction and 10 mg/kg/h for CRI. CRI was maintained for 1 h. Respiratory rates and blood pressures showed minimal changes; however, mild tachycardia and mild hypoxemia occurred, especially in group 3. There were some disparities between bispectral index score, electromyography and pedal withdrawal reflex test when measuring anesthetic depth. Additional premedications and/or analgesic agents would be helpful to avoid adverse effects of alfaxalone and provide improved cardiopulmonary functions.

Keyword

alfaxalone; bispectral index score; canine; total intravenous anesthesia

MeSH Terms

Analgesics
Animals
Anoxia
Dogs*
Electromyography
Premedication
Reflex
Respiratory Rate
Tachycardia
Analgesics