Ann Dermatol.  2017 Feb;29(1):108-110. 10.5021/ad.2017.29.1.108.

Are Peripheral Natural Killer Cells and Interleukin-21 Interrelated in Psoriasis Pathogenesis?

• Hegab DS
• Elgarhy LH
• Attia M

• KMID: 2368041
• DOI: http://doi.org/10.5021/ad.2017.29.1.108

Abstract

No abstract available.

MeSH Terms

Killer Cells, Natural*
Psoriasis*

Figure

• 

  Fig. 1 (A) Light side scatter analysis (SSC) of peripheral blood with a gate encompassing the CD3− (non T-cell) lymphocyte population (R2). (B) Flow cytometry dot blot analysis on peripheral blood lymphocytes isolated from a psoriatic patient showing different natural killer (NK) cell subsets according to CD56/CD16 positivity; CD3−CD56dim CD16− (R3), CD3−CD56dim CD16+ (R4), CD3−CD56bright CD16− (R5), and CD3−CD56bright CD16+ (R6) peripheral NK cell subsets. PerCP: peridinin-chlorophyll-protein complex, FITC: fluorescein isothiocyanate, PE: phycoerythrin.

Reference

1. Kim J, Krueger JG. The immunopathogenesis of psoriasis. Dermatol Clin. 2015; 33:13–23.

2. Spolski R, Leonard WJ. Interleukin-21: a double-edged sword with therapeutic potential. Nat Rev Drug Discov. 2014; 13:379–395.

3. Ottaviani C, Nasorri F, Bedini C, de Pità O, Girolomoni G, Cavani A. CD56brightCD16(-) NK cells accumulate in psoriatic skin in response to CXCL10 and CCL5 and exacerbate skin inflammation. Eur J Immunol. 2006; 36:118–128.

4. Li Q, Ye LJ, Ren HL, Huyan T, Li J, Shi JL, et al. Multiple effects of IL-21 on human NK cells in ex vivo expansion. Immunobiology. 2015; 220:876–888.

5. Sarra M, Caruso R, Cupi ML, Monteleone I, Stolfi C, Campione E, et al. IL-21 promotes skin recruitment of CD4(+) cells and drives IFN-γ-dependent epidermal hyperplasia. J Immunol. 2011; 186:5435–5442.

6. Dunphy S, Gardiner CM. NK cells and psoriasis. J Biomed Biotechnol. 2011; 2011:248317.

7. Son SW, Kim EO, Ryu ES, Kim TJ, Kim JN, Choi JE, et al. Upregulation of Fas and downregulation of CD94/NKG2A inhibitory receptors on circulating natural killer cells in patients with new-onset psoriasis. Br J Dermatol. 2009; 161:281–288.

8. Sivori S, Cantoni C, Parolini S, Marcenaro E, Conte R, Moretta L, et al. IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors. Eur J Immunol. 2003; 33:3439–3447.

9. Toomey JA, Gays F, Foster D, Brooks CG. Cytokine requirements for the growth and development of mouse NK cells in vitro. J Leukoc Biol. 2003; 74:233–242.

10. Strengell M, Matikainen S, Sirén J, Lehtonen A, Foster D, Julkunen I, et al. IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells. J Immunol. 2003; 170:5464–5469.