Blood Res.  2016 Dec;51(4):281-285. 10.5045/br.2016.51.4.281.

Toxic megacolon and interstitial pneumonia caused by cytomegalovirus infection in a pediatric patient with acute lymphoblastic leukemia receiving chemotherapy

  • 1Department of Pediatrics, Inje University Haeundae Paik Hospital, Busan, Korea.
  • 2Department of Radiology, Inje University Haeundae Paik Hospital, Busan, Korea.


No abstract available.

MeSH Terms

Cytomegalovirus Infections*
Drug Therapy*
Lung Diseases, Interstitial*
Megacolon, Toxic*
Precursor Cell Lymphoblastic Leukemia-Lymphoma*


  • Fig. 1 The patient developed fever, dyspnea, and abdominal distension on day 28 of induction. Chest X-ray (A) showed a newly developed pneumonic consolidation. Abdominal X-ray (B) showed a gas-filled colonic dilatation resembling toxic megacolon. A high-resolution computed tomography (HRCT; C, D) demonstrated the development of consolidations and ground-glass opacities in both lung fields.

  • Fig. 2 Sigmoidoscopy performed on day 40 revealed active bleeding with multiple hemorrhagic ulcers throughout the colon (A). Endoscopic biopsy revealed a chronic inflammatory ulcer (B). Histopathologic staining did not show any inclusion-bearing cells typical of CMV infection (owl's eye inclusions); however, immunohistochemical staining identified immunoreactivity for CMV antigen (C).

  • Fig. 3 Serial chest X-rays on day 54 showed progressive haziness in both lungs despite 2 weeks of ganciclovir treatment (A). Chest CT (B) on the same day (day 54) showed increased multifocal patchy consolidations and ground-glass opacities in both lung fields compared with previous chest CT images.


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