J Pathol Transl Med.  2016 Nov;50(6):482-485. 10.4132/jptm.2016.02.27.

Goblet Cell Carcinoid of the Rectum in a Patient with Neurofibromatosis Type 1

• Kang Y
• Choi JW
• Kim Y
• Oh HE
• Lee JH
• Kim YS

• KMID: 2361998
• DOI: http://doi.org/10.4132/jptm.2016.02.27

Abstract

No abstract available.

MeSH Terms

Carcinoid Tumor*
Goblet Cells*
Humans
Neurofibromatoses*
Neurofibromatosis 1*
Rectum*

Figure

• 

  Fig. 1. The rectum shows a combined occurrence of goblet cell carcinoid (GCC, empty arrows) and neuroendocrine tumors (filled arrows) as well as neurofibromatosis (A). GCC is mostly composed of small nests of signet-ring-like goblet cells (B), and the cytoplasmic mucin is readily identified with alcian blue pH 2.5 (C). (D) Synaptophysin immunostain clearly shows a few scattered neuroendocrine cells in GCC.

• 

  Fig. 2. Neuroendocrine tumors (NETs) consist of small uniform cells which exclusively form trabecular structures (A) and diffusely stained with synaptophysin (B). In the vicinity of both goblet cell carcinoid and NETs, proliferation of slender spindle cells morphologically compatible with neurofibromatosis (C) is evident with S-100 protein immunostain (D).

• 

  Fig. 3. The submucosal tumor in the jejunum is composed of bland-looking spindle cells (A) which highly expressed c-Kit by immunohistochemistry (B).

Reference

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