Cancer Res Treat.  2016 Oct;48(4):1313-1320. 10.4143/crt.2016.013.

The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study

• So KA
• Kim MJ
• Lee KH
• Lee IH
• Kim MK
• Lee YK
• Hwang CS
• Jeong MS
• Kee MK
• Kang C
• Cho CH
• Kim SM
• Hong SR
• Kim KT
• Lee WC
• Park JS
• Kim TJ

• KMID: 2356233
• DOI: http://doi.org/10.4143/crt.2016.013

Abstract

PURPOSE
The purpose of this study is to evaluate the impact of high-risk human papillomaviruses (HPVs) other than HPV 16/18 on the natural course of atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL).
MATERIALS AND METHODS
The study population was derived from the Korean HPV cohort (2010-2014). Women aged 20 to 60 who satisfied the criteria of having both HPV infection and abnormal cervical cytology of either ASC-US or LSIL were recruited from five institutions nationwide. Enrolled patients underwent cervical cytology and HPV DNA testing every 6 months.
RESULTS
A total of 1,158 patients were enrolled. The 10 most common HPV types were HPV 16 (12.3%), 58 (10.0%), 56 (8.8%), 53 (8.4%), 52 (7.7%), 39 (6.2%), 18 (6.0%), 51 (5.7%), 68 (5.1%), and 66 (4.6%). Among these patients, 636 women were positive for high-risk HPVs other than HPV 16 or 18, and 429 women were followed for more than 6 months. Cytology evaluations showed progression in 15.3% of women, no change in 22.6%, and regression in 62.1% of women at 12 months. In cases of HPV 58 single infection, a more highly significant progression rate, compared to other high-risk types, was observed at 6 months (relative risk [RR], 3.3; 95% confidence interval [CI], 2.04 to 5.30; p < 0.001) and 12 months (RR, 5.03; 95% CI, 2.56 to 9.91; p < 0.001).
CONCLUSION
HPV genotypes numbered in the 50s were frequent in Korean women with ASC-US and LSIL. HPV 58 was the second most common type, with a high progression rate of cervical cytology.

Keyword

Human papillomavirus; Genotype; Cytology

MeSH Terms

Atypical Squamous Cells of the Cervix
Cohort Studies*
Female
Genotype*
Human papillomavirus 16
Human Papillomavirus DNA Tests
Humans
Squamous Intraepithelial Lesions of the Cervix

Figure

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  Fig. 1. Flow diagram of study selection. HPV, human papillomavirus; ASC-US, atypical squamous cells of undetermined significance; LSIL, low-grade squamous intraepithelial lesion; ASC-H, atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion; HSIL, high-grade squamous intraepithelial lesion.

Reference

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