Pediatr Infect Vaccine.  2016 Aug;23(2):137-142. 10.14776/piv.2016.23.2.137.

Severe Cytomegalovirus Infection in a Late-Preterm Infant at 2 Months of Age

• Choi SY
• Lee KS

• KMID: 2353394
• DOI: http://doi.org/10.14776/piv.2016.23.2.137

Abstract

Severe cytomegalovirus (CMV) infection involving multiorgan is very rare except in very low-birth weight infants, or in immunocompromised pediatric patients. We report an unusual case of severe CMV infection involving multiple organs including the central nervous system, liver, lung, and gastrointestinal tract in a late-preterm infant at 2 months of age.

Keyword

Cytomegalovirus infection; Infant

MeSH Terms

Central Nervous System
Cytomegalovirus Infections*
Cytomegalovirus*
Gastrointestinal Tract
Humans
Infant*
Liver
Lung

Figure

• 

  Fig. 1 The brain magnetic resonance imaging (MRI) show high signal change at T1 weighted image, T2 weighted image (A, B) and high apparent diffusion coefficient (ADC) value at ADC map (C) in left postcentral gyrus (yellow arrow). These lesions were suspected with focal encephalitis with hemorrhage. After four months, follow up MRI show slightly improved focal encephalitis (D, E and F and T1, T2 weighted image and ADC map, respectively).

• 

  Fig. 2 The chest x-ray shows increased haziness in central area of both lungs.

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  Fig. 3 The esophagogastroduodenoscopy shows isolated erosive gastric mucosal lesions with hemorrhage on mid body of stomach.

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  Fig. 4 The graph and table shows the clinical progress and laboratory data. Ganciclovir administration was started at four days after admission. Thereafter, fever and laboratory data improved.

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