Korean J Anesthesiol.  1982 Mar;15(1):25-31.

The Effect of a Small Dose of Glycopyrrolate (Robinul) on the Heart Rate

• Jeong CY
• Lee CS

Abstract

The purpose of this study was to observe in healthy human volunteers the effect of a small dose of glycopyrrolate given intravenously, and to compare its effect with that of atropine. The results are as follows: 1) The usual dose of glycopyrrolate(0.2mg) showed no detectable change in the heart rate. 2) A small dose of glycopyrrolate(0.1mg) showed a decreasing tendency in the heart rate, but it was not a statistically significant decrease. 3) A small dose of glycopyrrolate(0.15mg) showed a significant decrease in the heart rate. 4) A small dose of glycopyrrolate(0.1mg) 10 minutes after glycopyrrolate(0.1mg) showed a significant increase in the heart rate. 5) A small dose of glycopyrrolate(0.15mg) 10 minutes after glycopyrrolate(0.1mg)did not cause a decrease in the heart rate. 6) A small dose of glycopyrrolate(0.1mg) 10 minutes after glycopyrrolate(0.15mg) showed a marked increase in the heart rate. 7) From the above results, it is infered that both glycopyrrolate and atropine have an effect on the sympathetic ganglia.

MeSH Terms

Atropine
Ganglia, Sympathetic
Glycopyrrolate*
Healthy Volunteers
Heart Rate*
Heart*
Atropine
Glycopyrrolate