J Korean Soc Radiol.  2010 Dec;63(6):565-568.

Local Recurrence of Secondary Hemangiosarcoma Following Breast Radiation Therapy: A Case Report

• Park AY
• Son EJ
• Kim H
• Woo HJ
• Kim JA
• Youk JH
• Jeong J

Abstract

Secondary hemangiosarcomas are a rare malignancy that can develop in breast tissue that has undergone prior radiation therapy. Post-irradiation hemangiosarcomas (PIHs) have been frequently described in the literature, although, to the best of our knowledge, the imaging findings of locally recurred PIHs have not been previously reported. We present imaging findings of a case of a locally recurring secondary hemangiosarcoma in the context of prior breast conservation surgery and radiation.

MeSH Terms

Breast
Hemangiosarcoma
Recurrence

Figure

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  Fig. 1 Imaging and histologic findings in a 57-year-old woman with breast PIH. A. A mammographic image taken three years after radiation. B. A mammographic image seven years after radiation shows progression of skin and trabecular thickening, compared with Fig. 1A. C. A sonographic image shows a 2.1×1.3 cm, irregular-shaped, angular marginated, heterogeneous hypoechoic mass with extension to the thickened skin layer (arrows). D. Microscopic findings of the mastectomy specimen show proliferation of the spindle cells with nuclear atypia (arrows) and a number of slit-like spaces containing RBCs (arrowheads), suggesting secondary hemangiosarcoma (H and E, ×400).

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  Fig. 2 Sonographic finding of locally recurred PIH. Breast sonography which was performed four months after mastectomy shows a circumscribed, hypoechoic mass in the subcutaneous layer around the incision scar.

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