J Korean Neurol Assoc.
2002 May;20(3):315-317.
A Case of Polymyositis associated with Hepatitis B infection
- Affiliations
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- 1Department of Neurology, College of Medicine, Ajou University, Korea. isjoo@madang.ajou.ac.kr
- 2Department of Pathology, College of Medicine, Ajou University, Korea.
Abstract
- Polymyositis(PM) is one of idiopathic inflammatory myopathy, characterized by proximal muscle weakness, myalgia and muscle enzyme elevation. Currently the main pathogenesis is well documented, the cell-mediated immunity. We experienced a case of polymyositis associated with hepatitis, developed after hepatitis B virus(HBV) infection. This virus-induced autoimmunity seems to result from the cross-reactivity between muscle protein and B-viral antigen, so called antigenic mimicry. This relation of PM and HBV is more significant in Korea because of the epidemicity of HBV infection.
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