J Korean Ophthalmol Soc.  2014 Jun;55(6):854-859.

Comparison of Dorzolamide-Timolol Fixed Combination and Latanoprost, Effects on Intraocular Pressure and Ocular Pulse Amplitude

• Jang SR
• Lee MV
• Ahn JH

Abstract

PURPOSE
To compare dorzolamide-timolol fixed combination (DTFC) and latanoprost with regard to their effects on intraocular pressure (IOP) and ocular pulse amplitude (OPA).
METHODS
Sixty eyes of 60 patients with open angle glaucoma or glaucoma suspect were included in the present study. Patients were divided into 2 groups, DTFC-treated (n = 30) and latanoprost-treated (n = 30). IOP and OPA were measured with dynamic contour tonometer (DCT) and Goldmann applanation tonometer (GAT), before and at least 1 month after treatment.
RESULTS
GAT IOP, DCT IOP and OPA decreased by 2.25 +/- 2.23 mm Hg, 1.97 +/- 2.06 mm Hg, and 0.14 +/- 0.88 mm Hg, respectively in the DTFC-treated group. In the latanoprost-treated group, GAT IOP, DCT IOP and OPA was reduced by 2.74 +/- 2.96 mm Hg, 2.06 +/- 3.50 mm Hg, and 0.69 +/- 1.07 mm Hg, respectively. There was no significant difference (p = 0.311) in the decline of IOP between the 2 groups, but OPA of the DTFC-treated group decreased less than the latanoprost-treated group (p = 0.032).
CONCLUSIONS
No significant differences were observed in the short-term decline of IOP between the 2 medications. However, the influence of DTFC on OPA appeared negligible in the latanoprost-treated group.

Keyword

Dorzolamide-timolol fixed combination; Dynamic contour tonometer; Intraocular pressure; Latanoprost; Ocular pulse amplitude

MeSH Terms

Glaucoma
Glaucoma, Open-Angle
Humans
Intraocular Pressure*

Figure

• 

  Figure 1. Change of ocular pulse amplitude (OPA) which was corrected by age and pretreatment intraocular pressure in lata-noprost (solid line) and dorzolamide-timolol fixed combination (DTFC, dotted line) groups OPA of latanoprost group de-creased more than that of DTFC group after treatment (p = 0.032, repeated measures ANOVA).

Reference

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