J Korean Ophthalmol Soc.  2012 Jun;53(6):807-812.

The Relations Between Progression of Peripapillary Chorioretinal Atrophy and Progression of Normal Tension Glaucoma

• Han JC
• Suh W
• Lim DH
• Kee C

Abstract

PURPOSE
To evaluate the relations between progression of glaucoma in visual field and peripapillary area change in normal tension glaucoma (NTG).
METHODS
We respectively evaluated 66 patients (66 eyes) with normal tension glaucoma; these patients were classified as progressive glaucoma group and non-progressive glaucoma group by visual field test. Interobserver and intraobserver agreement was evaluated for qualitative assessment. Zone beta change was measured by Image J (National Institute of Health, Bethesda, USA) by two methods. One method used paired t-test and the other method used CV (correlation of variation) to define significant progression of zone beta.
RESULTS
46 patients (46 eyes) were classified as progressive glaucoma and 20 patients (20 eyes) were classified as non-progressive glaucoma. There was no statistically significant different change of zone beta between two groups and there were no changes of zone beta over coefficient of variation (CV).
CONCLUSIONS
The measurement of change of zone beta seems to be of no use in recognition of progression in normal tension glaucoma.

Keyword

Normal tension glaucoma; Peripapillary atrophy; Progressive glaucoma; Progressive peripapillary atrophy; Zone beta

MeSH Terms

Atrophy
Glaucoma
Humans
Low Tension Glaucoma
Visual Field Tests
Visual Fields

Figure

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  Figure 1 Scatterplots showing the interobserver agreement between the two observers in measuring areas (pixel) of progression of peripapillary atrophy (beta zone).

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  Figure 2 Scatterplots showing the intraobserver agreement between each observation in measuring areas (log pixel) of progression of peripapillary atrophy (beta zone).

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  Figure 3 Distribution of coefficient of variation for progression of beta zone.

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