J Korean Ophthalmol Soc.  2012 Feb;53(2):268-275.

Photodynamic Therapy for Chronic Central Serous Chorioretinopathy According to Degree of Choroidal Hyperfluorescence

Affiliations
  • 1Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea. msagong@ynu.ac.kr

Abstract

PURPOSE
To compare the efficacy of photodynamic therapy (PDT) depending on the degree of hyperfluorescence based on indocyanine green angiography (ICGA) for treating chronic central serous chorioretinopathy (CSC).
METHODS
Twenty-three eyes of 23 patients with chronic CSC were recruited for the present study. The minimum follow-up period was six months. The total energy of PDT was reduced to 25 J/cm2 for 83 seconds. The baseline middle-phase ICGA findings were classified as intense or low hyperfluorescence depending on the degree of hyperpermeability from choriocapillaris. The change in mean best-corrected visual acuity, the resolution of subretinal fluid, recurrence rate, and complication were analyzed in relation to each ICGA finding at baseline.
RESULTS
The baseline ICGA findings showed intense hyperfluorescence in 11 eyes (47.8%) and low hyperfluorescence in 12 eyes (52.2%). The subretinal fluid resolved completely one month after a single application of low-fluence PDT in both groups. The subretinal fluid recurred in one of 12 eyes (8.3%) with low hyperfluorescence and in no eyes (0%) with intense hyperfluorescence. There was no statistically significant difference in the rate of recurrence between the two groups.
CONCLUSIONS
Low-fluence PDT appears to be an effective and safe treatment option for long-standing chronic CSC regardless of the degree of hyperfluorescence based on the ICGA.

Keyword

Chronic central serous chorioretinopathy; Indocyanine green angiography; Photodynamic therapy

MeSH Terms

Angiography
Central Serous Chorioretinopathy
Choroid
Eye
Follow-Up Studies
Humans
Indocyanine Green
Photochemotherapy
Recurrence
Subretinal Fluid
Triazenes
Visual Acuity
Indocyanine Green
Triazenes

Figure

  • Figure 1 Classification of indocyanine green angiography (ICGA) findings at baseline. The ICGA findings before PDT was applied to overlying areas of RPE leakage on FA, ICGA findings during the middle phase were classified as intense or low hyperfluorescence. First row demonstrates intense hyperfluorescence (A, B, C, D) and second row demonstrates low hyperfluorescence (E, F, G, H). M iddle phase of fluorescein angiography (A, E), early phase of ICGA (B, F), middle phase of ICGA (C, G) and late phase of ICGA (D, H).


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