J Korean Ophthalmol Soc.  2010 Aug;51(8):1142-1145.

A Case of an Orbital Myxoma

• Shin JH
• Jung JH
• Choi HY

Abstract

PURPOSE
Orbital myxoma is an extremely rare tumor. To date, only a few cases have been reported in the literature. The present study reports a case of an orbital myxoma and demonstrates the clinical and histological features.
CASE SUMMARY
A 37-year-old woman presented with a painless movable mass in the orbital margin of the left eye. Computed tomography of the orbit revealed a sharply outlined solid mass, and an excisional biopsy was performed. The excised specimen consisted of a 17x9x10 mm3 brownish mass of scattered spindle cells and small vascular spaces in a fibromyxoid background. Immunohistochemically, the tumor cells were not immunoreactive for SMA, S-100 protein or CD34. Histopathologic examination revealed the tumor to be a myxoma. There was no mass lesion in computed tomography of the orbit, and no recurrence or complications were found one month after removal.
CONCLUSIONS
When a patient presents with a painless and movable mass in the orbital area, orbital myxoma should be considered as a possible diagnosis. The orbital myxoma with bone invasion should be completely removed to prevent the lesion from recurring.

Keyword

Orbital myxoma

MeSH Terms

Adult
Biopsy
Eye
Female
Humans
Myxoma
Orbit
Recurrence
S100 Proteins
S100 Proteins

Figure

• 

  Figure 1. Preoperative and postoperative CT findings of the myxoma. There is sharply outlined solid mass with abutment of the left inferior orbital rim.

• 

  Figure 2. Surgically excised specimen consisted of a 17×9×10 mm3 solid and brownish mass.

• 

  Figure 3. Scattered spindle cells and small vascular spaces in a fibromyxoid background (H&E; (A) ×100, (B) ×400).

Reference

References

1. Lieb WE, Goebel HH, Wallenfang T. Myxoma of the orbit: a clinicopathologic report. Graefe's Arch Clin Exp Ophthalmol. 1990; 228:28–32.

2. Hidayat AA, Flint A, Marentette L, et al. Myxomas and angiomyxomas of the orbit: a clinicopathologic study of 6 cases. Ophthalmology. 2007; 114:1012–9.

3. Blegvad O. Myxoma of the orbit. Acta Ophthalmol. 1944; 22:131–40.

4. Bulkley BH, Hutchins GM. Atrial myxomas: a fifty year review. Am Heart J. 1979; 97:639–43.

5. Ferrans VJ, Roberts WC. Structural features of cardiac myxomas: histology, histochemistry, and electron microscopy. Hum Pathol. 1973; 4:111–46.

6. Ireland DC, Soule EH, Ivins JC. Myxoma of somatic soft tissues. A report of 58 patients, 3 with multiple tumors and fibrous dysplasia of bone. Mayo Clin Proc. 1973; 48:401–10.

7. Weiss SW, Goldblum JR, Enzinger FM. Enzinger and Weiss's soft tissue tumors. 2nd ed.St. Louis: Mosby;1988. p. 912–21.

8. Mottow-Lippa L, Tso MO, Sugar J. Conjunctival myxoma. A clinicopathologic study. Ophthalmology. 1983; 90:1452–8.

9. Patrinely JR, Green WR. Conjunctival myxoma. A clinicopathologic study of four cases and a review of the literature. Arch Ophthalmol. 1983; 101:1416–20.

10. Pe'er J, Hidayat AA. Myxomas of the conjunctiva. Am J Ophthalmol. 1986; 102:80–6.

11. Pe'er J, Ilsar M, Hidayat A. Conjunctival myxoma: a case report. Br J Ophthalmol. 1984; 68:618–22.

12. Bussy L. Le myxome de la cornée. Arch Ophthalmol. 1925; 42:33–8.

13. Daicker BC. Mulitiple myxoma of the eyelid. Ophthalmologica. 1979; 179:125–8.

14. Gifford SR. Multiple myxomas of the orbit. Arch Ophthalmol. 1931; 5:445–8.

15. Hashimoto H, Tsuneyoshi M, Daimaru Y, et al. Intramuscular myxoma. A clinicopathologic, immunohistochemical, and electron microscopic study. Cancer. 1986; 58:740–7.

16. Krueger EG, Polifrone JC, Baum G. Retrobulbar orbital myxoma and its detection by ultrasonography. Case report. J Neurosurg. 1967; 26:87–91.

17. Lamb HD. Myxoma of the orbit, with case report and anatomical findings. Arch Ophthalmol. 1928; 57:425–9.

18. BT Lee, JH lee, SH Kim, et al. One Case of Corneal Myxoma. J Korean Ophthalmol Soc. 1994; 35:202–5.

19. SJ Park, MJ Lee, MS Sung, et al. A Case of Conjunctival Myxoma. J Korean Ophthalmol Soc. 2008; 49:1676–9.

20. Spencer WH. Ophthalmic pathology: An atlas and textbook. 4th ed.Philadelphia: Saunders;1986. p. 2581–2.

21. Jones IS, Jakobiec FA. Disease of the orbit. Harper and Row: Hagerstown;1979. p. 470–3.

22. Yuen HK, Cheuk W, Luk FO, et al. Solitary superficial angiomyxoma in the eyelid. Am J Ophthalmol. 2005; 139:1141–2.

23. Miettinen M, Hockerstedt K, Reitamo J, et al. Intramuscular myxoma – a clinicopathologic study of twenty-three cases. Am J Clin Pathol. 1985; 84:265–72.