J Korean Ophthalmol Soc.  2010 Aug;51(8):1129-1132.

A Case of Low Grade Malignant Fibrous Histiocytoma in Lateral Canthus

• Kim CR
• Kim KH
• Yoo JM
• Seo SW

Abstract

PURPOSE
To report a case of malignant fibrous histiocytoma of the lateral canthal area that was diagnosed clinically as a benign epidermal inclusion cyst.
CASE SUMMARY
A 49 year-old man presented with a cutaneous mass involving the lateral canthal area. A 0.7-cm cystic lesion was freely movable and non-inflamed. After excisional biopsy, the results of immunohistochemical staining led to a final diagnosis of low-grade malignant fibrous histiocytoma. The specimen from excisional biopsy had margins positive for malignancy; the patient underwent a second procedure for complete resection, and that specimen had tumor-free margins.
CONCLUSIONS
Fibrous histiocytoma is a rare disease but may occur in the eyelid. Therefore, when an eyelid tumor progresses rapidly, malignant fibrous histiocytoma should be considered as a diagnosis.

Keyword

Lateral canthus; Malignant fibrous histiocytoma

MeSH Terms

Biopsy
Eyelids
Histiocytoma, Benign Fibrous
Histiocytoma, Malignant Fibrous
Humans
Rare Diseases

Figure

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  Figure 1. Clinical appearance of the right lateral canthal lesion at initial presentation shows a cystic and pedunculated nodule.

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  Figure. 2. Hematoxylin and eosin staining of the excised lesion shows storiform pattern of fibroblasts characteristic of fibrous histiocytoma (A) (H&E stain, ×200). The results of immunohistochemical staining is positive for CD68 (B) (CD68, ×200) and negative for CD34 (C) and smooth muscle actin (D) (CD34, SMA ×200).

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  Figure. 3. Intraoperative photograph shows a widely excised lesion.

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  Figure. 4. After 10 months, a postoperative photograph of the patient shows no recurrence of the tumor.

Reference

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