J Korean Ophthalmol Soc.  2007 Sep;48(9):1234-1241.

The Clinical Courses of Retinoblastoma Patients Who Underwent Bilateral Enucleation

• Han SB
• Kim JH
• Choung HK
• Kim SJ
• Khwarg SI
• Yu YS

Abstract

PURPOSE: To investigate the courses leading to bilateral enucleation in bilateral retinoblastoma patients.
METHODS
Medical records of 5 bilateral retinoblastoma patients who underwent bilateral enucleation were reviewed for patient information, history, change of tumor state during the treatment and the cause of bilateral enucleation.
RESULTS
Out of 48 bilateral retinoblastoma patients, both eyes were saved in 6 children, 1 eye was saved in 37 children, and the remaining 5 children lost both eyes. All patients who underwent bilateral enucleation were female and had no family history of retinoblastoma. At diagnosis, 3 children were 4 months old and the remaining 2 patients were 1 year and 1.5 years old each. Out of 10 eyes, 8 eyes were in Reese Ellsworth group V and the remaining 2 eyes were in group III. The initial treatment was enucleation of 1 eye followed by chemotherapy in 3 patients, and chemotherapy alone in 2 patients. Additional treatment included laser photocoagulation, cryotherapy, external beam radiation therapy and proton beam irradiation. Vitreous seeding, development of new tumors, and increase in tumor size despite of intensive, conservative treatment resulted in second enucleation. CONSLUSION: Most patients who underwent bilateral enucleation were 1 year old or younger at diagnosis of retinoblastoma. All patients had a progressed disease status at presentation and showed poor response to intensive, conservative treatment.

Keyword

Retinoblastoma; Enucleation; Bilateral retinoblastoma; Bilateral enucleation

MeSH Terms

Child
Cryotherapy
Diagnosis
Drug Therapy
Female
Humans
Infant
Light Coagulation
Medical Records
Protons
Retinoblastoma*
Protons

Figure

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  Figure 1. Orbital CT of case 1 shows calcification in both eyes.

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  Figure 2. Fundus photographs of the right eye of case 1. (A): multiple vitreous seedings on the posterior pole and regressed mass at 3 o'clock, (B) large new tumor mass at 2∼3 o'clock, and (C): multiple vitreous seedings in the inferonasal area.

Reference

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