J Korean Ophthalmol Soc.  1999 Jan;40(1):192-196.

The Effect of Indomethacin on Biphasic Intraocular Pressure Response to Laser Irradiaion of the Iris

• Kim YY

Abstract

Laser irradiation of the iris can induce acute increase in intraocular pressure (IOP) as well as hypotony. the author evaluated the effect of the prostaglandin on the biphasic IOP response. Of 14 animals, 7 experimental eyes were treated with topical indomethacin(indomethacin group) and 7 experimental eyes received topical saline(no indomethacin group) prior to laser photocoagulation, and the contralateral eyes were used as control eyes. Change in IOP was defined as [IOP of the experimental eye-IOP of the control eye]. Mean change in IOP reached its highest level 1 hour after laser treatment and subsequently decreased in the no indomethacin group(p=<0.0001, repeated measures ANOVA).However, indomethacin pretreatment showed no statistically significant changes throughtout the experimental period as compared with the baseline value(p=0.4, repeated measures ANOVA). Since indomethacin is known to be a potent ingibitor of prostaglandin synthase, our trsults suggest that prostaglandin plays a role on the biphasic IOP change.

Keyword

Argon laser; Biphasic intraocular pressure response; Indomethacin; Iris

MeSH Terms

Animals
Indomethacin*
Intraocular Pressure*
Iris*
Light Coagulation
Prostaglandin-Endoperoxide Synthases
Indomethacin
Prostaglandin-Endoperoxide Synthases