J Korean Pediatr Soc.  2002 Jul;45(7):891-895.

Renal Anomalies in Children with Turner Syndrome

• Kim JY
• Hong SY
• Park YM
• Park YH
• Chung WY

Abstract

PURPOSE: The prevalence of renal anomalies in Turner syndrome(TS) has been reported to vary from 33% to 60%. The purpose of this study was to clarify the true incidence of renal malformations in Korean TS.
METHODS
We evaluated 33 patients with Turner syndrome diagnosed by karyotype in Inje University Busan Paik hospital and Youngnam University from January 1995. Intravenous pyelography(IVP) was performed on all patients; abdominal ultrasonography and 99mTc-DMSA renal scan were performed on some. Cytogenetic analysis was performed on all patients with peripheral blood lymphocytes.
RESULTS
Of the total 33 patients, the karyotype showed 45, X in 18(54.5%) patients, mosaicism in 11(33.3%) patients and structural aberration in 4(12.2%) patients. The overall incidence of renal anomalies was 36.4%. The renal anomalies included four cases of horeshoe kidney, six cases of abnormal renal collecting system one case of single kidney and one case of malrotation. The incidence of renal anomalies in 45, X karotype(44.4%) showed a higher rate than that of mosaicism and structural aberration(26.7%), but there is no statistical significance.
CONCLUSION
The incidence of renal anomalies in Korean TS reveals 36.4%. This rate is similar to other foreign TS studies. We recommend that renal ultrasonography or IVP for investigation of renal anomalies should be done as a screening procedure for the better quality of life in patients with TS.

Keyword

Turner syndrome; Renal anomalies; Karyotype, Korean

MeSH Terms

Busan
Child*
Cytogenetic Analysis
Humans
Incidence
Karyotype
Kidney
Lymphocytes
Mass Screening
Mosaicism
Prevalence
Quality of Life
Technetium Tc 99m Dimercaptosuccinic Acid
Turner Syndrome*
Ultrasonography
Technetium Tc 99m Dimercaptosuccinic Acid