J Korean Soc Med Inform.  2003 Dec;9(4):349-373.

Recent Progress in Medical Imaging: Mloecular Imaging in Living Subjects

  • 1The Crump Institute for Molecular Imaging, Department of Molecular & Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA. jmin@mednet.ucla.edu
  • 2Department of Radiology and Oncology, University of Cambridge School of Clinical Medicine, Cambridge CB2 2QQ, UK.


Recent progress in the development of non-invasive imaging technologies continues to strengthen the role of molecular imaging biological research. These tools have been validated recently in variety of research models, and have been shown to provide continuous quantitative monitoring of the location(s), magnitude, and time-variation of gene delivery and/or expression. This article reviews the use of radionuclide, magnetic resonance, and optical imaging technologies as they have been used in imaging gene delivery and gene expression for molecular imaging applications. The studies published to date demonstrate that noninvasive imaging tools will help to accelerate pre-clinical model validation as well as allow for clinical monitoring of human diseases.


Molecular Imaging; Gene Expression Imaging; Reporter Gene Imaging; Non-Invasive Imaging; Positron Emission Tomography; Single Photon Emission Computed Tomography; Magnetic Resonance Imaging; Optical Imaging; Bioluminescence; Fluorescence; Molecular Beacons; Reporter Probes; Tracers

MeSH Terms

Diagnostic Imaging*
Gene Expression
Magnetic Resonance Imaging
Molecular Imaging
Optical Imaging
Positron-Emission Tomography
Tomography, Emission-Computed, Single-Photon
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