Does Laparoscopic Unilateral Ovarian Cystectomy Reduce the Ovarian Reserve in Early Postoperative Period?

Chun, Sungwook; Jeon, Gyun Ho; Cho, Hyun Jin; Ji, Yong Il

Abstract

OBJECTIVES
The aim of this study was to evaluate the impact of laparoscopic unilateral ovarian cystectomy for benign ovarian disease on the ovarian reserve in early postoperative period.
METHODS
We retrospectively reviewed the medical records and laboratory data of patients aged 18~45 years with regular menstruation before gynecologic surgery. Thirty-three patients were included in this study who received scheduled laparoscopic unilateral ovarian cystectomy in Inje University Haeundae Paik Hospital, and received serum anti-Mullerian hormone (AMH) tests preoperatively and 3 days after operation. The patients were divided into three groups according to the histologic diagnosis: Group 1 included thirteen patients who were diagnosed as ovarian endometriosis. Group 2 included nine patients who were diagnosed as mature cystic teratoma. Group 3 included eleven patients who were diagnosed as other benign cyst.
RESULTS
Postoperative day 3 AMH levels were significantly decreased after unilateral ovarian cystectomy compared to preoperative AMH levels in all patients (3.28+/-0.34 ng/ml vs 4.27+/-0.41 ng/ml, P=0.000). In subgroup analysis, there were significant differences between pre- and postperative AMH levels in group 1 (3.99+/-0.65 ng/ml vs 2.68+/-0.51 ng/ml, P=0.001). Postoperative AMH levels were also lower than preoperative levels in group 2 (4.07+/-0.88 ng/ml vs 3.03+/-0.71 ng/ml, P=0.011), and in group 3 (4.78+/-0.67 ng/ml vs 4.18+/-0.53 ng/ml, P=0.033).
CONCLUSION
Our results suggest that laparoscopic unilateral ovarian cystectomy reduce the ovarian reserve in early postoperative period irrespective of histologic diagnosis.