Korean J Nosocomial Infect Control.  2016 Jun;21(1):31-36. 10.14192/kjnic.2016.21.1.31.

Seroprevalence of Anti-hepatitis B Virus, Anti-hepatitis A Virus, and Anti-varicella Zoster Virus Antibodies in Nursing Students from 2009 to 2013

• Park JH
• Shon JA

• KMID: 2328188
• DOI: http://doi.org/10.14192/kjnic.2016.21.1.31

Abstract

BACKGROUND
Nursing students may be exposed to patients with infectious diseases such as hepatitis B and hepatitis A through needle stick injuries or close contact during their clinical practice. This study surveyed the presence of antihepatitis B virus (anti-HBV), anti-hepatitis A virus (anti-HAV), and anti-varicella zoster virus antibodies in nursing students before the initiation of their clinical practice to help prevent subsequent infections.
METHODS
From 2009 to 2013, the junior students of a nursing college in Jeollabuk-do were tested for antibodies against the hepatitis B, hepatitis A, and varicella zoster viruses before the initiation of their clinical practice.
RESULTS
The students tested positive for anti-HBV (46.2-57.1%), anti-HAV (0-10.5%), and anti-varicella zoster antibodies (80.2-90.2%). No significant differences in the positivity rates were observed with respect to the year of their enrollment.
CONCLUSION
This study was a survey of the seroprevalence of anti-HBV, anti-HAV, and anti-varicella zoster antibodies in nursing students before they started their clinical practice. The positivity rate of anti-HAV was lower than 10%. In order to prevent infection, it is necessary to test nursing students for the presence of antibodies against hepatitis B, hepatitis A, varicella, measles, mumps, and rubella, and check their vaccination history as recommended in the adult immunization schedule. Vaccination must be recommended for students who test negative for the respective antibodies.

Keyword

Hepatitis A antibodies; Hepatitis B antibodies; Nursing student; Seroprevalence; Varicella

MeSH Terms

Adult
Antibodies*
Chickenpox
Communicable Diseases
Hepatitis A
Hepatitis A Antibodies
Hepatitis B
Hepatitis B Antibodies
Herpes Zoster*
Herpesvirus 1, Cercopithecine*
Herpesvirus 3, Human
Humans
Immunization Schedule
Jeollabuk-do
Measles
Mumps
Needlestick Injuries
Nursing*
Rubella
Seroepidemiologic Studies*
Students, Nursing*
Vaccination
Antibodies
Hepatitis A Antibodies
Hepatitis B Antibodies

Reference

References

1. Centers for Disease Control and Prevention.Summary report for blood and body fluid exposure data collected from participating healthcare facilities. (June 1995 through December. 2007; http://www.cdc.gov/nhsn/PDFs/NaSH/NaSH-Report-6-2011.pdf.

2. Choi JS, Kim KS. Application and evaluation of a web-based education program on blood-borne infection control for nurses. J Korean Acad Nurs. 2009; 39:298–309.

3. Kim OS, Yoon SW. Exposure and immune status of health care workers accidentally exposed to hepatitis B virus in a healthcare setting. J Korean Biol Nurs Sci. 2009; 11:120–7.

4. Yun YH, Chung YK, Jeong JS, Jeong IS, Park ES, Yoon SW, et al. Epidemiological characteristics and scale for needlestick injury in some university hospital workers. Korean J Occup Environ Med. 2011; 23:371–8.

5. Lee CS, Hwang JH, Seon SY, Jung MH, Park JH, Lee HB. Exposure to blood and body fluids for medical students during clerkship. Korean J Med. 2008; 74:500–5.

6. Park JH, Chon HK, Jeong SH, Hwang JH, Lee CS, Lee HB. Nursing students’ exposure to blood and body fluids in clinical practicum. Korean J East-West Nurs Res. 2010; 16:70–5.

7. Centers for Disease Control and prevention.Guideline for infection control in health care personnel. 1998; http://www.cdc.gov/hicpac/pdf/InfectControl98.pdf.

8. Ministry of Employment and labor.Occupational health and safty management standard. http://www.law.go.kr/LSW/lsSc.do?menuId=0&p1=&sub-Menu=1&nwYn=1&section=&tabNo=&query=%EC%82%B0%EC%97%85%EC%95%88%EC%A0%84%EB%B3%B4%EA%B1%B4%EB%B2%95%20%EC%8B%9C%ED%96%89%EA%B7%9C%EC%B9%99#undefined.

9. Korea Institute for Healthcare Accreditation.Accreditation standard of healthcare organization. http://www.koiha.kr/member/kr/board/establish/establish_BoardView.do.

10. Miller BL, Lindley MC, Ahmed F, Wortley PM. Student immunity requirements of health professional schools: vaccination and other means of fulfillment-United States, 2008. Infect Control Hosp Epidemiol. 2011; 32:908–11.

11. Loulergue P, Fonteneau L, Armengaud JB, Momcilovic S, Levy-Brühl D, Launay O; Studyvax survey group.. Vaccine coverage of healthcare students in hospitals of the Paris region in 2009: the Studyvax survey. Vaccine. 2013; 31:2835–8.

12. Kang JH, Kim HB, Sohn JW, Lee SO, Chung MH, Cheong HJ, et al. Adult immunization schedule recommended by the Korean society of infectious diseases, 2007. Infect Chemother. 2008; 40:1–13.

13. Oh HY, Park JY. Immunization, knowledge, and preventive health behaviors to hepatitis a in university students. Korean J Health Educ Promot. 2011; 28:83–95.

14. Kim MS, Kim ES, Chang YJ, Huh HJ, Chae SL, Lee JH. Seroepidemiology of hepatitis a among healthcare workers and their response to vaccination recommendation at a Korean hospital. Infect Chemother. 2009; 41:272–8.

15. Yun SW, Lee WK, Cho SY, Moon SH, Shin HD, Yun SY, et al. The seroprevalence rate, vaccination rate and seroconversion rate of hepatitis A in central region of Korea. Korean J Gastroenterol. 2011; 57:166–72.

16. Pavlopoulou ID, Daikos GL, Tzivaras A, Bozas E, Kosmidis C, Tsoumakas C, et al. Medical and nursing students with suboptimal protective immunity against vaccine-preventable diseases. Infect Control Hosp Epidemiol. 2009; 30:1006–11.

17. Yamazhan T, Durusoy R, Tasbakan MI, Tokem Y, Pullukcu H, Sipahi OR. . Turkish Nursing Hepatitis Study Group. Nursing students’ immunisation status and knowledge about viral hepatitis in Turkey: a multi-centre cross-sectional study. Int Nurs Rev. 2011; 58:181–5.

18. Mäding C, Jacob C, Münch C, von Lindeman K, Klewer J, Kugler J. Vaccination coverage among students from a German health care college. Am J Infect Control. 2015; 43:191–4.

19. Chodick G, Ashkenazi S, Lerman Y. The risk of hepatitis a infection among healthcare workers: a review of reported outbreaks and seroepidemiologic studies. J Hosp Infec. 2006; 62:414–20.

20. Park JY, Lee JB, Jeong SY, Lee SH, Lee MA, Choi HJ. Molecular characterization of an acute hepatitis A outbreak among healthcare workers at a Korean hospital. J Hosp Infect. 2007; 67:175–81.

21. Langley JM, Hanakowski M. Variation in risk for nosocomial chickenpox after inadvertent exposure. J Hosp Infect. 2000; 44:224–6.

22. Bhatti VK, Budhathoki L, Kumar M, Singh G, Nath A, Nair GV. Use of immunization as strategy for outbreak control of varicella zoster in an institutional setting. Med J Armed Forces India. 2014; 70:220–4.

23. Kellie SM, Makvandi M, Muller ML. Management and outcome of a varicella exposure in a neonatal intensive care unit: lessons for the vaccine era. Am J Infect Control. 2011; 39:844–8.

24. Lindley MC, Lorick SA, Spinner JR, Krull AR, Mootrey GT, Ahmed F, et al. Student vaccination requirements of U.S. health professional schools: a survey. Ann Intern Med. 2011; 154:391–400.