J Lab Med Qual Assur.  2002 Dec;24(2):201-207.

Measurement of PT, aPTT, and Fibrinogen by Automatic Coagulation Analyzer, ACL9000

Affiliations
  • 1Department of Laboratory Medicine, National Health Insurance Medical Center, Goyang, Korea. yakim@nhimc.or.kr

Abstract

BACKGROUND: Newly developed ACL9000 automatic coagulation analyzer was evaluated in measurement of prothrombin time(PT), activated partial thromboplastin time(aPTT) and fibrinogen.
METHODS
We studied precision including withtin-run and between-day precision. Normal reference ranges for PT, aPTT and fibrinogen were obtained in 60 healthy normal controls. The heparin sensitivity for aPTT and heparin interference for PT and fibrinogen were also determined. Lastly ACL9000 was compared with another coagulation analyzer, MLA Electra 1600.
RESULTS
Precision of PT, aPTT and fibrinogen were acceptable, mostly. The normal reference ranges were as followings: 10.7-12.4 sec for PT, 28.7-40.8 sec for aPTT and 165-468 mg/dL for fibrinogen. The ranges of aPTT were from 49.8 sec to 84.7 sec in therapeutic heparin concentration(0.2-0.4 IU/mL) and heparin interfered determination of PT and fibrinogen in high concentrations. The comparability between ACL9000 and MLA Electra 1600 was good in determinations of PT and fibrinogen but not in determination of aPTT.
CONCLUSIONS
We concluded that the performance of ACL9000 was acceptable and ACL9000 would be a useful analyzer for routine coagulation tests.

Keyword

ACL9000; Automatic coagulation analyzer; Prothrombin time; Activated partial thromboplastin time; Fibrinogen
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