J Korean Surg Soc.  2007 May;72(5):419-422.

Primary Gastric Mixed Type Choriocarcinoma

Affiliations
  • 1Department of Surgery, Kosin University College of Medicine, Busan, Korea. yoonky@ns.Kosinmed.or.kr

Abstract

A primary gastric choriocarcinoma (PGC) is a rare tumor, with only approximately 140 cases reported in the international medical literature. A choriocarcinoma is a rapidly invasive, widely metastatic, human chorionic gonadotropin (HCG)-producing neoplasm, which is usually intrauterine and gestational, the pathogenesis of which is still uncertain. Herein, the case of primary gastric choriocarcinoma, associated with an adenocarcinoma in a 72-year old man, who presented with gastrointestinal bleeding and a gastric mass, clinically suspicious of a gastric adenocarcinoma, with GB and CBD stones, is reported. Thus, a radical subtotal gastrectomy and lymph node dissection, with reconstruction, and a cholecystectomy, with choledocholithomy T tube insertion, were performed. The resected specimen was found to be a Borrmann type I tumor, and a histological examination revealed this to be a primary gastric choriocarcinoma, associated with an adenocarcinoma and a syncytiotrophoblast, which was immunostained using human chorionic gonadotropin (HCG). The serum HCG level on the 7th postoperative day was found to be 962 mIU/ml. At the same time, the tumor rapidly recurred and disseminated to the liver. The patient died three months after the initial diagnosis.

Keyword

Primary gastric choriocarcinoma

MeSH Terms

Adenocarcinoma
Aged
Cholecystectomy
Choriocarcinoma*
Chorionic Gonadotropin
Diagnosis
Female
Gastrectomy
Hemorrhage
Humans
Liver
Lymph Node Excision
Pregnancy
Trophoblasts
Chorionic Gonadotropin
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