J Korean Soc Transplant.  2002 Jun;16(1):84-89.

Comparison of Tacrolimus and Cyclosporine in Kidney Transplantation

Affiliations
  • 1Dongsan Kidney Institute, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. k780121@dsmc.or.kr

Abstract

PURPOSE: The calcineurin inhibitors, tacrolimus and cyclosporine, have been used as primary immunosuppressant in renal transplantation. Tacrolimus has been shown to be an effective alternative to cyclosporine for the prevention of acute rejection but the two drugs are different in side-effect profile. This retrospective study compares the efficacy and safety of tacrolimus-based versus cyclosporine-based immunosuppression in patients receiving kidney transplantation.
METHODS
There were 177 consecutive recipients of kidney graft; 90 received cyclosporine-based immunosuppression therapy, and 87 received tacrolimus-based immunosuppression. Graft and patient survival rate, incidence of acute rejection and side effects were compared.
RESULTS
The 3-year graft survival rate of cyclosporine and tacrolimus was similar (93.0% vs. 91.4%). The incidence of acute rejection was significantly less in the tacrolimus group compared with the cyclosporine group (10.3% vs. 31.1%, P<0.05). Incidence of impaired renal function, gastrointestinal disorder, tremor, hypertension and hyperkalemia were comparable in both treatment groups. Higher incidence of posttransplant diabetes, allopecia, abdominal pain and headache was reported in the tacrolimus group, whereas that of hypercholesterolmeia, hirsuitism, and gum hyperplasia was more frequent with cyclosporine group.
CONCLUSION
Tacrolimus is as effective as cyclosporine in patient and graft survival in kidney transplantation. Due to different side-effect profiles, it is needed to develop individualized immunosuppressive strategies in renal transplant recipients.

Keyword

Kidney transplantation; Tacrolimus; Cyclosporine; Survival; Side effect

MeSH Terms

Abdominal Pain
Calcineurin
Cyclosporine*
Gingiva
Graft Survival
Headache
Humans
Hyperkalemia
Hyperplasia
Hypertension
Immunosuppression
Incidence
Kidney Transplantation*
Kidney*
Retrospective Studies
Survival Rate
Tacrolimus*
Transplantation
Transplants
Tremor
Calcineurin
Cyclosporine
Tacrolimus
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