Psychiatry Investig.  2013 Jun;10(2):196-199.

The Contingent Negative Variation in Remitted Paediatric Bipolar Patients: No Evidence of Abnormality

• Banerjee N
• Sinha VK
• Jayaswal M
• Desarkar P

Abstract

Although the Contingent Negative Variation (CNV) paradigm has been useful in schizophrenia, limited research involving such paradigm in subjects with Bipolar Disorder (BD) has produced contradictory findings. To the best of our knowledge, no study has investigated CNV in Paediatric Bipolar Disorder (PBD) subjects. Thirty remitted PBD patients and thirty matched healthy control group subjects participated in the study. No significant between group main effect could be found for either CNV latency or amplitude. We propose that CNV is unlikely to be a true endophenotype of BD. However, absence of CNV finding during euthymic phase in BD may help us in advancing our understanding of BD and such finding may, in fact, have some specificity with regard to differentiating BD from schizophrenia.

Keyword

Child, Adolescent, Bipolar disorder; Contingent negative variation

MeSH Terms

Bipolar Disorder
Contingent Negative Variation
Endophenotypes
Humans
Schizophrenia
Sensitivity and Specificity