Korean J Urol.  2013 Jan;54(1):69-72.

Metastasis of Renal Cell Carcinoma to the Bladder

• Doo SW
• Kim WB
• Kim BK
• Yang WJ
• Yoon JH
• Jin SY
• Song YS

Abstract

Renal cell carcinoma is an uncommon source of bladder metastases. Here we report a case of renal cell carcinoma that metastasized to the bladder. A 73-year-old woman complained of gross hematuria. Abdominopelvic computerized tomography showed a bladder mass and a heterogenous enhancing mass in the lower pole of the left kidney with left vein thrombosis. The pathological analysis of the resected bladder specimen revealed metastatic renal cell carcinoma of the clear cell type.

Keyword

Neoplasm metastasis; Renal cell carcinoma

MeSH Terms

Carcinoma, Renal Cell
Female
Hematuria
Humans
Kidney
Neoplasm Metastasis
Thrombosis
Urinary Bladder
Veins

Figure

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  FIG. 1 Cystoscopy revealed a sessile mass on the right lateral bladder wall.

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  FIG. 2 Abdominopelvic computerized tomography showed a heterogeneously enhancing mass in the lower pole of the left kidney with left renal vein thrombosis and an enhancing polypoid lesion in the right lateral wall of the urinary bladder.

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  FIG. 3 (A) Section from the bladder tumor showing carcinoma with clear cell morphology consistent with metastatic renal cell carcinoma. The mucosa was mostly eroded and the bladder wall was invaded by proliferation of polygonal tumor cells in nests with rich, thin fibrovascular stroma (H&E, ×100). (B) Each tumor cell had abundant, light, eosinophilic to clear cytoplasm and a central large nucleus with a prominent nucleolus. They were positive for CD10 and vimentin and negative for cytokeratin 7 (CK7), CK20, and p63. The findings were therefore consistent with metastatic renal cell carcinoma, clear cell type, rather than primary carcinoma of the urinary bladder (Light microscopy, ×200).

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