Nucl Med Mol Imaging.  2016 Mar;50(1):3-12. 10.1007/s13139-016-0393-1.

PET/MRI: Technical Challenges and Recent Advances

  • 1Molecular Imaging Research & Education Laboratory, Department of Electronic Engineering, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 04107, Korea.


Integrated positron emission tomography (PET)/magnetic resonance imaging (MRI), which can provide complementary functional and anatomical information about a specific organ or body system at the molecular level, has become a powerful imaging modality to understand the molecular biology details, disease mechanisms, and pharmacokinetics in animals and humans. Although the first experiment on the PET/MRI was performed in the early 1990s, its clinical application was accomplished in recent years because there were various technical challenges in integrating PET and MRI in a single system with minimum mutual interference between PETand MRI. This paper presents the technical challenges and recent advances in combining PET and MRI along with several approaches for improving PET image quality of the PET/MRI hybrid imaging system.


Anatomical and functional information; MRI; PET; PET/MRI hybrid imaging system
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