Nucl Med Mol Imaging.
2011 Jun;45(2):139-144.
Intratumoral Heterogeneous F-18 Fluorodeoxyglucose Uptake Corresponds with Glucose Transporter-1 and Ki-67 Expression in a Case of Krukenberg Tumor: Localization of Intratumoral Hypermetabolic Focus by Fused PET/MR Image
- Affiliations
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- 1Department of Nuclear Medicine, Seoul National University College of Medicine, 28, Yeongeon-dong, Jongno-gu, Seoul 110-799, South Korea.
- 2Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea.
- 3Departments of Radiology, Seoul National University Hospital, Seoul, South Korea.
- 4Cancer Research Institute, Seoul National University, Seoul, South Korea. kangkw@snu.ac.kr.
Abstract
- The expression of glucose transporters (Glut-1, Glut-3), hexokinase-II, and Ki-67 has been proposed to explain intratumoral heterogeneous F-18 fluorodeoxyglucose (FDG) uptake. We report a case of Krukenberg tumor with intratumoral heterogeneous FDG uptake which corresponded well with the expression levels of Glut-1 and ki- 67. Fused positron emission tomography (PET)/magnetic resonance (MR) imaging was helpful for localizing the metabolically active area in the tumor specimen. This report elucidates the relationship between the intratumoral heterogeneous FDG uptake and biologic heterogeneity, and shows the usefulness of PET/MR in research on intratumoral heterogeneity.
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