Nat Prod Sci.  2015 Jun;21(2):122-127. 10.0000/nps.2015.21.2.122.

Gastrodia elata Blume Attenuates 2, 4-Dinitrochlorobenzene-induced Atopic Dermatitis-like Skin Lesions in Balb/c Mice and SD Rats

Affiliations
  • 1Department of Oriental Pharmacy, Wonkwang University, Iksan 570-749, South Korea. ymlee@wku.ac.kr

Abstract

Gastrodia elata Blume is a well-known kind of natural products used as a folk medicine for thousands of years. However, anti-atopic dermatitis-like effects of G. elata Blume had not been evaluated until now. The aim of the present study is to investigate the protective effects of water extract from the roots of G. elata Blume (GE) on 2, 4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions using balb/c mice. Combination treatment of GE (at a dose of 12.5 mg/kg body weight by administrated per os + 0.5 mg/cm2 as ointment to apply on ear and dorsal skin) was significantly inhibited spleen weight, ear thickness, levels of serum immunoglobulin E and number of mast cells, compared with that of 2, 4-dinitrochlorobenzene-included groups without GE. Furthermore, combination application by oral administration plus by ointment of GE significantly inhibited the histamine release from rat peritoneal mast cells. These results suggest that combination treatment of oral administration plus ointment form of GE could be helpful as a potentially natural pharmaceutical treatment on atopic-like dermatitis.

Keyword

Atopic dermatitis; Gastrodia elata Blume; Skin lesion; 2, 4-Dinitrochlorobenzene

MeSH Terms

Administration, Oral
Animals
Biological Products
Body Weight
Dermatitis
Dermatitis, Atopic
Ear
Gastrodia*
Histamine Release
Immunoglobulin E
Immunoglobulins
Mast Cells
Medicine, Traditional
Mice*
Rats*
Skin*
Spleen
Water
Biological Products
Immunoglobulin E
Immunoglobulins
Water
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