Lab Med Online.  2014 Jan;4(1):8-14.

Mobilization of Peripheral Blood Stem Cells for Autologous Transplantation in Patients with Hematologic Malignancies

Affiliations
  • 1Department of Laboratory Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea. sgkim@cu.ac.kr
  • 2Division of Hematology-Oncology, Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.

Abstract

BACKGROUND
Autologous peripheral blood-stem cell transplantation (autoPBSCT) is the treatment of choice for hematologic malignancy, because the technique requires neither general anesthesia nor surgical intervention, amongst many other advantages. Despite these benefits, the risk of hematologic malignancy, as well as the effect of patient age and sex on the prediction of successful collection of autoPBSCT are still unclear. The purpose
of this study was to examine whether the hematologic diagnosis of the disease, and age or sex affect the mobilization of CD34+ cells and mononuclear cells.
METHODS
We retrospectively investigated 30 (6 multiple myeloma, 11 diffuse large B-cell lymphoma, 8 acute myeloid leukemia, 2 acute lymphoid leukemia, and 3 T-cell lymphoma) patients who underwent autoPBSCT between 2008 and 2011 at Daegu Catholic University Hospital.
RESULTS
Patients with multiple myeloma had the highest average of both mononuclear cell (MNC) (2.07+/-0.67x10(8) cells/kg) and CD34+ cell (1.28+/-0.58x10(6) cells/kg) counts. Patients with T-cell lymphoma had both the lowest MNC (1.23+/-0.49x10(8) cells/kg) and CD34+ cell (0.20+/-0.6x10(6) cells/kg) counts. Male patients showed greater collected CD34+ cell counts (0.96+/-1.38x10(6) cells/kg) and MNC counts (1.71+/-0.76x10(8) cells/kg) than the female patients. Patients under the age of 44 had higher collected CD34+ cell counts (0.96+/-1.37x10(6) cells/kg) but lower counts of MNC (1.49+/-0.74x10(8) cells/kg).
CONCLUSIONS
The collected MNC and CD34+ cell counts varied between the types of malignancies, and with respect to sex and age. However, only collected MNC counts were significantly different (P<0.05) among the different types of malignancies.

Keyword

Hematologic malignancy; Autologous peripheral blood-stem cell transplantation (autoPBSCT); Mononuclear cells; CD34+ cells; Mobilization
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