Korean J Urol.  1999 Mar;40(3):292-296.

Serum Immunosuppressive Acidic Protein(IAP) as a Tumor Marker for Renal Cell Carcinoma

• Kim SJ
• Choi HY
• Chai SE

Abstract

PURPOSE: We assessed the significance of immunosuppressive acidic protein(IAP) as a tumor marker for renal cell carcinoma.
MATERIALS AND METHODS
The serum concentration of IAP was determined in 88 patients with renal cell carcinoma and in 12 healthy adults by turbidometric immunoassay. We examined the prognostic value of the serum IAP level and its association with other clinicopathological parameters such as tumor stage and grade.
RESULTS
The mean value of serum IAP in patients with renal cell carcinoma (643.0+/-447.5microgram/ml) was statistically higher than that of the control group (320.4+/-79.0microgram/ml). Positive rates of IAP were noticed as 22.2%, 56.9%, 57.9%, and 100% of patients in stages T1, T2, T3, and T4, respectively. The mean value of serum IAP in metastatic patients(1159.6+/-711.7microgram/ml) was higher than that in non-metastatic patients(553.5+/-313.4microgram/ml)(p=0.001). In high grade tumors (Fuhrman`s nuclear grade III/IV), IAP level(693.5+/-385.14microgram/ml) was higher than that(507.1+/-305.44microgram/ml) of low grade tumors(grade I/II) (p=0.006).
CONCLUSIONS
Serum IAP seems to be useful as diagnostic and followup tumor marker in patients with renal cell carcinoma.

Keyword

Renal cell carcinoma; Tumor markers; Biological; Immunosuppressive acidic protein

MeSH Terms

Adult
Carcinoma, Renal Cell*
Follow-Up Studies
Humans
Immunoassay
Biomarkers, Tumor